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1/27/2012
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Cancer News on the Net® is dedicated to bringing patients and their
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Image-guided ablation for Renal Cell Carcinoma: An Update
Renal cell carcinoma (RCC) is a very common clinical problem with an estimated 58,240 patients diagnosed in 2010 [1]. This represents a doubling in the number of RCCs diagnosed in the last 50 years, and a five-fold increase in the diagnosis of small, less than 3 cm tumors over the last 20 years [1]. Identifying these tumors at a smaller size has a significant impact on patient prognosis for two reasons. One is that there are few available effective chemotherapies and as a result, the only hope for cure is surgical resection or physical destruction of the tumor. The smaller the tumor at diagnosis, the more likely it is that complete treatment will be possible. The other is that smaller tumors generally have a more indolent natural history and a lower likelihood of developing metastatic disease. Historically, renal cancers were frequently diagnosed in the advanced stages once they began to cause symptoms related to mass effect from the tumor itself, or blood in the urine. As a result, it was often incurable. There are three primary reasons for the increase in RCC diagnosis, especially smaller tumors: 1) the use of cross-sectional imaging has increased dramatically during this time and these renal tumors are identified incidentally on imaging performed for other reasons (e.g. motor vehicle accident, abdominal pain, etc.) 2) improvements in CT, US, and MRI technology now make it possible to identify even very small renal tumors that previously would not have been appreciated and 3) there is a small, but real increase in the rate of renal cancer in the United States, the cause of which is unknown.
Radical nephrectomy (removal of the entire kidney along with the tumor) was for many years the standard of care for the treatment of renal cell carcinoma. However, this has changed over the last several decades as surgical techniques have improved and smaller tumors have been diagnosed. Partial nephrectomy (removal of the tumor and a small margin of normal kidney) has now become the standard of care for the treatment of small RCCs in most centers, and is increasingly performed laparoscopically, limiting the associated morbidity. Clinical studies have shown that this less invasive therapy is as effective as, and safer than radical nephrectomy for the treatment of small RCCs without evidence of local or distant spread [2, 3]. [more]
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Multiple Myeloma Treatment: Experimental drug combination ‘encouraging’ in relapsed multiple myeloma
SAN DIEGO–When the targeted drug bortezomib stops working in patients with advanced multiple myeloma, the patients survive only an average of five months longer. [more]
Cancer Prevention and Diet: Fight cancer with your fork this holiday season
The overall key to finding cancer-fighting foods is to look for a lot of color. In the winter, root vegetables like carrots, parsnips and beets can add a burst of color and taste. [more]
Chronic Lymphocytic Leukemia Research - Results of DNA study offers clues for future treatments
SAN DIEGO—The most comprehensive search to date of DNA abnormalities in chronic lymphocytic leukemia (CLL) has unearthed several new altered genes that drive this common blood cancer, a finding that [more]
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